4 edition of Bioactive conformation found in the catalog.
Includes bibliographical references and index.
|Statement||volume editor, Thomas Peters ; with contributions by S.V. Evans ... [et al.].|
|Series||Topics in current chemistry -- 272-273|
|Contributions||Peters, T., Evans, S. V. 1959-|
|LC Classifications||QD481 .B617 2008|
|The Physical Object|
|Pagination||2 v. :|
|ISBN 10||3540490779, 3540490795, 3540490809|
|ISBN 10||9783540490777, 9783540490791, 9783540490807|
|LC Control Number||2007942195|
A prerequisite for the design of analogs of natural products, with more accessible synthetic routes, is the availability of their bioactive conformation. Nuclear Magnetic Resonance (NMR) spectroscopy and X-ray crystallography are the two techniques of choice to investigate the structure of natural products. Background. One of the imperative aspects in drug design and development is to perceive corresponding bioactive conformations which determine the physical and biological properties of drugs .Conformation generation is the kernel in computer-aided drug design (CADD) methods such as molecular docking , pharmacophore construction and matching [5,6], 3D .
Bioactive Carbohydrates and Dietary Fibre is intended to be an international journal focused on dietary fibre, bioactive polysaccharides and glycoproteins. It will include original studies and comprehensive reviews on the primary structure, molecular characteristics including conformation, size and shape, and bioactivities demonstrated by studies using in vitro, cell . [click for university staff page] Jonathan Clayden and his research group work on the construction of molecules with defined shapes, and are particular interested in exploring and exploiting molecular conformation. The shape of a molecule dictates its function, and understanding conformational effects allows us to make molecules that behave in specific ways.
Waals, dipole–dipole and hydrophobic interactions). This E–S formation has been described by a “lock and key” model that has been extended by the notion of “induced fit”, that is, S binding causes a subtle change of active site conformation resulting in even better binding. Edible seaweeds are rich in bioactive compounds such as soluble dietary fibers, proteins, peptides, minerals, vitamins, polyunsaturated fatty acids and antioxidants. Previously, seaweeds were only used as gelling and thickening agents in the food or pharmaceutical industries, recent researches have revealed their potential as complementary medicine. The red, brown and .
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Bioactive Conformation I (Topics in Current Chemistry ()) (v. 1) Bioactive conformation book Edition by Thomas Peters (Editor)Format: Hardcover. "Bioactive Conformation I contains eight chapters on quite different topics within the theme of the series.
it will be essential reading for any researcher working in any area that involves binding of a substance to a protein." (T. Grindley, Journal of the American Chemical Society, Vol. (2), )Brand: Springer-Verlag Berlin Heidelberg. Spatial Screening for the Identification of the Bioactive Conformation of Integrin Ligands.
Timo Weide, Armin Modlinger, Horst Kessler. Pages Dynamics and Thermodynamics of Ligand–Protein Interactions. Homans. From the reviews:"Bioactive Conformation I contains eight chapters on quite different topics within the theme of the Bioactive conformation book.
it will be essential reading for any researcher working in any area that involves binding of a substance to a protein." (T. Grindley, Journal of the American Chemical Society, Vol.
(2), ) Read more. Modulation of the Bioactive Conformation of Transforming Growth Factor β: Possible Implications of Cation Binding for Biological Function. Bioactive conformation / [Sergiy E Afonin;] Home.
WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Book: All Authors / Contributors: Sergiy E Afonin. Find more information about: ISBN: OCLC Number. NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands Marcel J.
Blommers, Andre Strauss, Martin Geiser, Paul Ramage, Helmut Sparrer, Wolfgang Jahnke Pages Quantitative Analysis of STD-NMR Spectra of. adshelp[at] The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86A. The Bioactive Conformation of Human Parathyroid Hormone.
Structural Evidence for the Extended Helix Postulate. Stephen M. Condon, Isabelle Morize, Shelley Darnbrough, Christopher J.
Burns, Bruce E. Miller, Joanne Uhl, Kathleen Burke, Navinchandra Jariwala, Kenneth Locke, Paul H. Krolikowski, N. Vasant Kumar, and ; Richard F. Labaudiniere. We found that, in general, the drug-like molecules present bound to proteins in the Protein Data Bank (PDB) can access easily the bioactive conformation and in fact for 73% of the studied molecules the “bioactive” conformation is within 3kbT from the most stable conformation in solution as determined by DFT/SCRF calculations.
Locking the dihedral angle of the northern phenyl substituent into the preferred bioactive conformation (Figure 4) was envisaged as a design strategy to improve binding efficiency.
As a base case, we assessed conformational freedom of the N3- and C2′-unsubstituted system 22 with relaxed scan, density-functional calculations.[ 30 ].
Bioactive molecules comprise many soluble molecules, including growth factors, angiogenic factors, cytokines, hormones, DNA, siRNA, and immunosuppressant drugs, which interact with and modulate the activity of a cell (Holland and Mikos, ; Kasper and Mikos, ).For instance, early in embryonic development, the fate of the uncommitted cells towards the.
Also, little is available in the areas of bioactive and nutraceutical compounds in bovine and human milks, while books on other mammalian species are non-existent. Bioactive Components in Milk and Dairy Products extensively covers the bioactive components in milk and dairy products of many dairy species, including cows, goats, buffalo, sheep.
This unique book also discusses partial structure-functionality (bioactivities) relationships based on conformational studies. This comprehensive work can be used as a handbook to explore potential applications in foods, pharmaceuticals, and. Dr. Shaoping Nie is a professor at State Key laboratory of Food Science and Technology, Nanchang University of China.
Nie’s research interests are focused on the structure, conformation and bioactivities of bioactive polysaccharides and dietary fibre and the relationship of their structure and bioactivities, also, Dr. Nie worked on developing functional products by using bioactive.
Bioactive conformation - The geometry adopted by a ligand when it binds to its biological target. Pharmacokinetics - The study of absorption, distribution, metabolism and excretion (ADME) of bioactive compounds.
Pharmacophore - Specific 3D arrangement of chemical groups common to active molecules and essential to their biological activities. Conformation generation is a ubiquitous problem in molecule modelling. Many applications require sampling the broad molecular conformational space or perceiving the bioactive conformers to ensure.
The rationale behind rigidification is to keep a molecule in its bioactive conformation while eliminating alternative conformations that may interact with other targets. By keeping molecules in a certain conformation, activity may be improved, binding site interactions may be enhanced, and/or side effects could be minimised.
While one undergoes either O- or C-allylation to provide  or  bicyclic compounds, the unique conformation of the other diastereomer allows an unconventional alkene isomerization to.
This review covers the recent opinions emerged on the nature of the ligand-receptor interaction, and the development of suitable models for the determination of the bioactive conformation of peptide ligands active towards m-opioid receptors. Keywords: Opioid peptides, endomorphins, bioactive conformation, antinociception.
Ortho-substituted biphenyl moieties are widely used in drug herein report a successful use of the perpendicular conformation of the alpha-substituted phenylcyclopropyl groups to mimic the aplanar, biologically active conformation of the ortho-substituted biphenyl moieties to achieve structural is exemplified by the design and synthesis of a series of highly.
Of interest to us in this commentary is the combination of a single conformational state to describe a protein, usually derived from x-ray crystallographic data, with a ligand designed to adopt the required bound state (the bioactive conformation) in .Abstract Quantifying the relative energy of a ligand in its target-bound state (i.e.
the bioactive conformation) is essential to understand the process of molecular recognition, to optimize the.